GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs703842 | 1 | rs6581155 | chr12:58178162 | TSFM | chr12:58176536-58191367:+ | -0.3 | -5.45 | 4.0E-7 | Multiple sclerosis |
| THYM | cis | rs975752 | 1 | rs6584347 | chr10:101906963 | BLOC1S2 | chr10:102033713-102046439:- | -0.45 | -4.9 | 3.89E-6 | Schizophrenia |
| THYM | cis | rs975752 | 1 | rs6584349 | chr10:101942556 | BLOC1S2 | chr10:102033713-102046439:- | -0.49 | -5.28 | 8.32E-7 | Schizophrenia |
| THYM | cis | rs7552404 | 1 | rs6593585 | chr1:76140273 | ACADM | chr1:76190043-76229353:+ | 0.3 | 4.24 | 5.22E-5 | Blood metabolite levels;Acylcarnitine levels |
| THYM | cis | rs9815354 | 1 | rs6599170 | chr3:41772718 | ULK4 | chr3:41288091-42003660:- | 1.03 | 11.59 | 7.14E-20 | Diastolic blood pressure |
| THYM | cis | rs9815354 | 1 | rs6599175 | chr3:41786009 | ULK4 | chr3:41288091-42003660:- | -1.03 | -10.42 | 2.13E-17 | Diastolic blood pressure |
| THYM | cis | rs9815354 | 1 | rs6599176 | chr3:41788492 | ULK4 | chr3:41288091-42003660:- | -1.02 | -11.47 | 1.24E-19 | Diastolic blood pressure |
| THYM | cis | rs9815354 | 1 | rs6599178 | chr3:41842129 | ULK4 | chr3:41288091-42003660:- | 1.02 | 10.9 | 1.98E-18 | Diastolic blood pressure |
| THYM | cis | rs9815354 | 1 | rs6599179 | chr3:41855284 | ULK4 | chr3:41288091-42003660:- | 1.02 | 11.47 | 1.22E-19 | Diastolic blood pressure |
| THYM | cis | rs11723261 | 1 | rs6599318 | chr4:243968 | ZNF718 | chr4:53272-156488:+ | 0.68 | 7.3 | 8.88E-11 | Immune response to smallpox vaccine (IL-6) |
| THYM | cis | rs56775891 | 1 | rs6650631 | chr18:77566535 | KCNG2 | chr18:77623668-77659815:+ | 0.52 | 4.14 | 7.41E-5 | Schizophrenia |
| THYM | cis | rs1875620 | 1 | rs66551258 | chr9:91560197 | C9orf47 | chr9:91605778-91611055:+ | -0.27 | -4.71 | 8.28E-6 | Response to statins (LDL cholesterol change) |
| THYM | cis | rs2275426 | 1 | rs6656992 | chr1:46333068 | CCDC163P | chr1:45960581-45965646:- | -0.49 | -5.85 | 6.8E-8 | Body mass index |
| THYM | cis | rs6540731 | 1 | rs6657900 | chr1:212400866 | NEK2 | chr1:211836115-211848967:- | -0.17 | -4.53 | 1.74E-5 | Intelligence (childhood) |
| THYM | cis | rs2275426 | 1 | rs6661910 | chr1:46290632 | CCDC163P | chr1:45960581-45965646:- | -0.49 | -5.86 | 6.53E-8 | Body mass index |